Staphysagria remedy is most often used for complaints involving the nerves, such as neuralgia, teething problems, cystitis, sties, blepharitis (inflammation of the eyelid), and headaches that feel as if a weight is pressing out from the forehead. It is also useful for women with new sexual partners, who have pain during sexual intercourse.

Staphysagria is often given acutely for the physical effects of suppressed anger. In these cases the patient's anger and resentment is clearly felt, but not expressed. The force of it rebounds upon the body, producing physical symptoms. It is important for the homeopath to realize that acute states of Staphysagria can arise in any constitutional type, and also that the anger of the person who is constitutionally Staphysagria is usually much less apparent than in acute cases. Staphysagria's anger is often so well suppressed that it is not only unexpressed; it is not even felt. (This compares with many Natrums, whose sadness may be completely suppressed much of the time.) This gives most Staphysagrias a certain mellowness or sweetness that belies the time-bomb of anger ticking away beneath the surface of consciousness.